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Together, this evidence suggests that stress-induced BBB dysfunction associated with combat may have allowed pyridostigmine to penetrate the brain and exert central neurotoxic effects that are characteristic of Gulf War Syndrome

the results from this phase 3b clinical trial may not be generalizable to the broader population of hospitalized patients with schizophrenia who are initiating LAIs 1,3 The approval of ARISTADA was based on the phase 3, 12-week, pivotal study that compared the 441 mg and 882 mg monthly doses to placebo at Day 85

Goldstein, L

It also clearly demonstrates that the role of RABGAP1 in APP trafficking is dependent on its GAP activity, suggesting that it mediates this effect through RAB protein inactivation

The effects might be additive, synergistic, or potentially counteractive depending on specific circumstances

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