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They combined this targeting sequence with a proapoptotic domain, D(KLAKLAK)2, that disrupts mitochondrial membranes when internalized by cells

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Noyce said he'd seen people, mostly in their teens and twenties, at the hospital who were "really very disabled" from using high quantities of nitrous oxide, needing to use a walking frame or wheelchair, and others who were incontinent or unable to get an erection