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) Thoughts of self-harm or harm to others Hallucinations, paranoia, or severe confusion 3

Under oxidative stress, DNA methyltransferases DNMT1 and DNMT3B, along with sirtuin SIRT1, relocate to CpG islands (CGIs) and form complexes with PRC2 subunits like EZH2 and EED, leading to localized DNA methylation (172)

In the nervous system, ferroptosis may lead to cognitive impairment (224, 274) and produce pathogenic T lymphocytes that lead to dysfunction in neuronal and glial cells (252, 538)

Corticosteroids, NSAIDs, thromboxane inhibitors, cyclosporine, statins, and monoclonal antibodies have shown limited success, partly due to nonspecific immunosuppression

alpha-1 antitrypsin, AAT

3.4 Post-traumatic stress disorder (PTSD) Gut microbiota alterations in PTSD are increasingly evident in human cohorts, with consistent depletion of SCFA-producing taxa and enrichment of inflammatory pathobionts, while taxa level signatures vary across geography and trauma type (Bajaj et al., 2019