Homocysteine, a risk factor for cardiovascular disease, interferes with the translational reading of SECIS in the expression of GPx1 [53] and, therefore, inhibits the expression of GPx1 promoting the increase of oxygen species reagents that inactivate nitric oxide and cause endothelial dysfunction
In both neuroimmune and neurodegenerative disorders, cells of both immune and neural lineagesadaptive lymphocytes (T and B), innate phagocytes (neutrophils, macrophages) plus resident nervous-system populations (astrocytes, microglia, neurons)constitute indispensable collaborators
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There are two isoforms of GLS which are encoded by two genes in mammals, the kidney-type GLS1 and the liver-type GLS2
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Global, regional, and national burden of osteoarthritis, 19902020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
