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1B), the kinetics of the Hcy-dependent cell death were almost identical in both cases (Fig

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Instead of merely inhibiting the active sites of proteins and reducing their activity, DUB inhibitors can completely degrade the target proteins, effectively eliminating the residual activity that often leads to side effects with traditional drugs

241 In addition, there is evidence that corticosteroids cannot inhibit p38MAPK activation, and that p38MAPK inhibitors combined with corticosteroids enhance the inhibitory effect of corticosteroids on cytokines produced by macrophages in patients with COPD mediated by LPS

Cardiovasc Toxicol (2014) 14(1):8397