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Domain Weighting for Hospitals Receiving Scores on Fewer Than Four Domains In the FY 2015 IPPS/LTCH PPS final rule (79 FR 50084 through 50085), we adopted a policy that hospitals must receive domain scores on at least three of four quality domains in order to receive a TPS, for the FY 2017 program year and subsequent years

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The condition may be related to a dysfunction in Kreb's cycle, governing cellular respiration, and resembles the gastrointestinal component of mitochondrial metabolism disorders , such as MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes)

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Taken together, these data demonstrate that mitochondrial function is intrinsically linked to 5FU sensitivity, and that its inhibition may provide an opportunity to increase 5FU efficacy