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The short answer: just about everyone

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Additionally, overloading Vitamin B12 through injections can lead to a buildup of this nutrient in the body, which can cause serious health problems

Weeks 14: 250 mcg (0.25 mg) once weekly to establish baseline tolerance

The plasmids used in this study were shown as follows: pcDNA3.13 Flag, pcDNA3.1-rNdufa1-3 Flag-C, pcDNA3.1-rCREB1-3 Flag-C, pDualuc-Basic, Ndufa1-pDualuc-Basic were from UNIBIO Biological Technology (Changsha, China)