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Possible side effects: erythema, dry skin, itching, and in the long term a modest but existing risk of accelerated skin aging and theoretically skin cancer (to be viewed in perspective with the benefits)

Gene expression: GHK-Cu has been documented to up- or downregulate over 4,000 human genes in cell-culture models, affecting pathways related to inflammation, tissue repair, and antioxidant defense (PMID 29986520)

Standardized delirium assessments and sedative exposure should be accounted for

The bottom line Nutritional supplements are popular as ever, but theyre under-regulated and their benefits are often overblown

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In another study [48], chondrocytes overexpressed IGF-1, and these genetically modified chondrocytes were cultured on a polyglycolic acid scaffold in vitro