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Int Immunopharmacol 99:108002

second, it binds to cellular GST/GSH, depleting its intracellular content to weaken the efflux of chemotherapy drugs in tumor cells

doi: 10.1038/s41420-022-00841-9 35 EisenreichW.RudelT.HeesemannJ.GoebelW

With this aim in mind, a disruptor (PZIF67-AT) based on the modification of an inhibitor (3-amino-1,2,4, triazole) and poly(ethylene glycol) on zeolitic imidazole framework nanoparticles bridged by 2-methylimidazole and cobalt ions was prepared (Sang et al