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In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

Storage in the Body Creatine Approximately 95 percent of creatine is found in skeletal muscle, with trace amounts stored in the brain, liver, kidneys, and pancreas

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Biomed Pharmacother 103:13021311 Acknowledgements The present study was financially supported by research affairs of Iran University of Medical Sciences

Therefore, more studies are needed to confirm the role and specific mechanisms of TMAO in MAFLD