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Specifically, 7687% of beta2-toxin-producing Clostridium perfringens were significantly higher in children with ASD compared to control children, indicating that these opportunistic pathogens thrive in immature or compromised immune systems 107

(Lond.) 124 , 153164 (2013)

As for the mechanism by which IGF-1 regulates skeletal growth and maintenance, it has been proposed that the actions of IGF-1 on bone occur through multiple modes: endocrine, autocrine, and paracrine