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Chronic and uncontrolled hyperglycemia leads to the formation of advanced glycated end products (AGEs), leading to the generation of reactive oxygen species (ROS) and stimulation of inflammatory cascade and resulting in DM complications [15-16]

IPA also regulates the activity of key metabolic enzymes by optimizing substrate utilization and respiratory efficiency, promoting fatty acid -oxidation and glucose oxidation, ensuring efficient substrate flow into the tricarboxylic acid cycle(TCA cycle), and supporting the efficient operation of the ETC (Liu et al., 2025)

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IPA, as a potent inducer of PGC-1, can significantly upregulate the expression and activity of PGC-1 by activating AMP-dependent protein kinase(AMPK) and silencing the deacetylase regulatory protein(SIRT1) (Majeed et al., 2021)