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On the basis of earlier studies in rabbits 29,31 , we developed a minimally invasive surgery for advanced keratoconus, inserting a thick, large-diameter BPCDX into an intrastromal pocket within the recipient cornea to counteract pathologic stromal thinning and normalize refraction by reshaping the central and peripheral cornea, without removing recipient tissue

These include: Fatigue, weakness, and pallor are the most common symptoms that appear in the early stages

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However, there is considerable individual variation, and many patients notice little change initially

If you would like to be evaluated for vitamin B12 or you already know you are deficient and have the genetic variant MTHFR, Dr