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However, that the hepatotoxicity of APAP results from the production of the reactive metabolite N -acetyl- p -benzoquinoneimine (NAPQI/NABQI) that can deplete glutathione, react with cellular macromolecules, and initiate cell death, is now beyond dispute

9fi), and clusters with highly similar phenotypes were combined

The levels of each variable were set as + 1, 0, and 1, and a total of 9 experimental runs (2 3 + 1 runs as the center point) were performed

Glossitis: Inflammation of the tongue, causing it to become red, swollen, and smooth

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