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Future investigations should integrate single-cell omics with artificial intelligence (AI) to construct multidimensional receptor-ligand-phenotype maps, enabling personalized therapeutic strategies

Moreover, IR disrupts mitochondrial dynamics, promoting fission and reducing fusion, and blunts mitophagy via inhibition of the PINK1/Parkin pathway

Both SOD-dependent agents, SOD@ARA290-HBc and pMnSOD, leverage SODs direct antioxidant activity within a bioengineered vessel to improve drug delivery [69, 77]