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Cortagen targets the cerebral cortex and may support neurological function in lupus patients who experience neuropsychiatric symptoms, a feature present in up to 75% of SLE patients at some point in their disease course

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Moreover, the fatsoluble vitamin influences the human microbiota by retaining intestinal homeostasis accomplished due to an increased cellular production of antimicrobial proteins from, for example macrophages and monocytes through RXR/VDR-signaling induction of promotor sequences of cathelicidin antimicrobial peptide etc., thereby preventing intestinal bacterial translocation and, on a large scale, the development of auto-inflammatory / metabolic dysfunctions, along with its role in maintaining intestinal epithelial cell integrity (production of nitric oxide due to upregulation of endothelial nitric oxide synthase (eNOS)), which in turn minimizes epithelial damage caused by bacterial lipopolysaccharides (LPS) [151, 162,163,164,165,166,167,168]

Results obtained from randomized clinical trials, however, were inconsistent and in some circumstances have indicated that antioxidants increase cancer risk (Klein et al., 2011

m , Venn diagram of differentially expressed genes in response to treatments