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Furthermore, highly toxic peroxynitrite ions (ONOO - ) produced via O 2 - react with nitric oxide (NO) to damage proteins, nucleic acids, and phospholipids in cells by circumventing antioxidative enzymes ( Figure 1 )

To confirm the expression of SOD1 variants, NSC-34 cells, a motor neuron-like hybrid cell line, were transfected with SOD1 WT or SOD1 G93A constructs

doi: 10.1073/pnas.1716161115

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