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Unless there is clear evidence of primary bladder pathology (e.g., small capacity under anesthesia, Hunner lesions), patients should have a multidisciplinary evaluation including assessment for neuropathic pain and psychological profile

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Since adverse hepatotoxic effects are common with remdesivir, severe impairment of hepatic function is a strict contraindication of its use [63, 64]

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doi: 10.1038/s41556-018-0042-2 231 AndersonCMMacleodKF