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Chen Z-Y, Ieraci A, Teng H, Dall H, Meng C-X, Herrera DG, Nykjaer A, Hempstead BL, Lee FS (2005) Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway

Lets use a few examples

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Pickart was studying liver tissue regeneration and noticed that a small peptide fraction isolated from human plasma significantly accelerated repair in older liver cells, restoring their behavior to something closer to younger cells

Systemic inflammation or low hormones can delay recovery

Activation of amylin receptor complexes