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however, the rate of AGE formation from glucose is orders of magnitude slower than that induced by glucose-derived dicarbonyl precursors generated intracellularly, and it now seems likely that raised intracellular glucose is the primary initiating event in the formation of both intracellular and extracellular AGEs [29]

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doi: 10.1042/BST20140008

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Delicate metabolic control and coordinated stress response critically determine antifungal tolerance of Candida albicans biofilm persisters