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Tian, H., Lin, S., Wu, J., Ma, M., Yu, J., Zeng, Y., Liu, Q., Chen, L., & Xu, J

Efficacy of l-ornithine l-aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study

Mediators of endothelial cell activation are diverse and include proinflammatory cytokines (tumor necrosis factor (TNF ), interleukin-1 (IL-1 )), bacterial (lipopolysaccharide) and endogenous toxins (oxLDL), vasoconstrictors (angiotensin II, endothelin-1), mechanical forces (shear stress, stretch), and extracellular matrix proteins (fibronectin, fibrinogen) [13, 5254]

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However, a study revealed that synthesis of fatty acid transporter (FAT) protein 2 and FAT was reduced after NP treatment of hepatocytes (63), preventing transport of fatty acids from the blood to the liver, indirectly impeding synthesis of fatty acids in the liver

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