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Tick-Borne Meat Allergy: Many Carry Alpha-Gal Antibodies Without Symptoms More Health News Medically Reviewed on 6/23/2026 Mayo Clinic: "Vitamin B-12." National Institutes of Health: "Vitamin B12." Oregon State University: "Vitamin B12." Top What Happens if You Take Too Much Vitamin B12 Related Articles 22 Healthy Foods High in B VitaminsAny deficiency of B vitamins can lead to various health conditions

Gastric acid and pepsin in the stomach release B12 from these dietary proteins, allowing it to bind with R-proteins (haptocorrins) secreted in saliva

These conditions include tropical sprue and nontropical sprue (celiac disease)

Although MTHFR does not directly cause B12 deficiency, research suggests that people with the MTFHR C677T mutation have a significantly higher risk of deficiency