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Preclinical research has examined AHK-Cu in fibroblast and dermal cell culture models for its effects on collagen and glycosaminoglycan synthesis via TGF- pathway interaction

Often, vitamin B12 shots or supplements will be prescribed, and in rare cases, blood transfusions may be needed

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We have also performed a pooled genetic screen on vacuolar proteins and found that conditional depletion of several vacuolar transporters can partially phenocopy the autophagy-activating effect of the V-ATPase dysfunction (Supplementary Fig

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