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Cisplatin causes ROS generation, depletes the antioxidant capacity of cerebellar cells, leading to cerebellar oxidative damage

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Alhuraiji A, Kantarjian HM, Jabbour EJ, Boddu PC, Ravandi F, Borthakur G , DiNardo CD, Daver N, Kadia TM, Pemmaraju N, Pierce S, Garcia-Manero G, Cortes JE

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Temperature-induced changes in the conformation around this modification site could affect how well the fatty acid chain interacts with albumin, potentially altering the medication pharmacokinetics, how long it stays active in your body