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The ASK1-MAP kinase cascades in mammalian stress response

Furthermore, cells maintained their membrane integrity, attested by Zombie red labeling (Figure 2B)

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Finally, many studies have interrogated the role of requisite amino acids (i.e., cysteine, glutamate, and glycine) or metabolic cofactors that regenerate GSH (i.e., NADPH) 20,21,22,23,24,25 in GSH synthesis

Redox balance is essential for maintaining cellular signaling and activation 21

Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP