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Increased albumin levels in the brain activate transcriptional signals associated with TGF-, which can maintain inflammation and induce epileptogenesis (93, 144)

This could trigger a positive feedback cycle whereby protein aggregates trigger the aggregation of other proteins in a chain reaction that eventually captures elements of the proteostatic mechanisms in place to counteract them

Finding the "best" set of features to build a predictive model is a complex combinatorial problem and available methods are generally classified into two categories: filtering methods (those which rank individual features according to some criteria) and more involved wrapper algorithms, which use classification methods directly to evaluate a particular set of features

(February 2013)

& Nagy, L

Molecular and Cellular Neuroscience, 45 , 192199