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T., & Kim, T.-Y

were the first to encounter CHAC1 expression in the context of cancer cell death ( CHAC1 gene is highly upregulated in HNSC cancer after treatment with nisin which was then followed by cell death ( CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues ( CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed ( CHAC1 is upregulated by the ATF4-CHOP cascade and leads to cell death by perturbation of the redox homeostasis through changes in the ROS levels ( The pathological significance of CHAC1 and ferroptosis extends beyond cancer, having also been established in various neurological disorders

doi: 10.1007/s00204-021-03048-6

10.1016/j.fmre.2023.08.011 57 WangX.LiM.DiaoK.WangY.ChenH.ZhaoZ.et al (2023b)

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