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Many DNIs are mutualfor instance, the drug affects micronutritional status, and the micronutrient affects drug metabolism, contributing to adverse drug effects (Figure 1) [28,29,30]

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As a result, there may be a notable rise in MTX-related toxicities due to prolonged, persistent, or elevated MTX plasma levels

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Int Rev Cytol 1981, 68: 251305

To correct for section artifacts, we do not show the subchondral bone plate surface area per se, but express the subchondral bone plate thickness as a ratio of the subchondral bone plate area to the subchondral bone area