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Key unresolved questionsincluding the exact temporal sequence and causal relationship between NTFs signaling dysfunction and mitochondrial impairment in human PD, the existence of an irreversible threshold beyond which intervention is ineffective, and the universal applicability of preclinical findings to sporadic PDmust be addressed through rigorous, human-relevant research

All patients received pemafibrate 0.2 mg (0.1 mg twice daily) for 24 weeks

Improves Metabolic Health: It helps improve glucose uptake and increase insulin sensitivity

The ability to act as an antioxidant is the ability to generate superoxide

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Muscle loss is a significant practical concern, with studies showing that 30-40% of weight lost on GLP-1 agonists can be lean mass if protein intake and resistance training are neglected