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Evatt ML et al

10.1038/nrgastro.2017.119 46 JrgensenJ.MortensenP

However, in high-risk populationsincluding patients with chronic kidney disease, granulomatous diseases, and primary hyperparathyroidismhypercalcemia may develop at substantially lower thresholds due to impaired Vitamin D 3 metabolism or unregulated extrarenal 1-hydroxylase activity

The rapid absorption not only maximizes the therapeutic potential of the vitamins but also minimizes any waiting period associated with conventional supplements

In a recent preprint, low or absent CD4 + T cell and CD8 + T cell responses were noted in patients with severe long COVID 49 , and a separate study found lower levels of CD8 + T cells expressing CD107a and a decline in nucleocapsid-specific interferon--producing CD8 + T cells in patients with long COVID compared with infected controls without long COVID 50