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The effect of sperm DNA damage on assisted reproduction outcomes

Acta 510 , 123141 (2020)

doi: 10.1016/j.jaut.2022.102974 223 BernardKLogsdonNJBenavidesGASandersYZhangJDarley-UsmarVMet al

During human volunteer studies at the University of Arizona, researchers noted significant sexual arousal effects attributed to MC4R activation which ultimately led to the development of PT-141 (Bremelanotide) as a more selective derivative

Conclusions from research studies published to date are limited due to small sample sizes, lack of randomization in some studies, and a need for more precise tests of thiamin nutritional status