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The Ca axis is associated with activation of phospholipase C or GMP-specific phosphodiesterase, followed by the release of intracellular Ca into the cytosol to activate downstream signaling proteins consisting of CREB and NFAT transcription factors mainly to regulate migration [90, 92]

Both influence VEGF expression, though through different upstream regulators

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The standard-curve plasma samples are then stored at 20C and further processed alongside the pharmacokinetic study samples [2]

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