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IARC Scientific Publications No

Takahashi Y, Biller BMK, Fukuoka H, et al

doi: 10.1016/j.cell.2008.07.032 314 RoshalMKimBZhuYHNghiemPPlanellesV

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These linkers are designed to be relatively stable at physiological pH (~7.4) but undergo hydrolysis in the acidic endosomes or lysosomes (pH 4.56.0) of tumor cells