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First, autophagy plays a protective role by inhibiting oxidative damage and apoptosis in CuSO 4 -induced testicular injury and spermatogenesis disruption, and second, autophagy plays an adverse role by promoting ferroptosis, thus aggravating the toxicity caused by CuSO 4 [100]

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Then these are sealed by sealing machine in an appropriate manner

The Pyruvate Dehydrogenase complex oxidizes pyruvate produced by glycolysis to acetyl-CoA and is a major control point of TCA cycle activity for carbohydrate metabolism (Gray et al., 2014)

Although research on the mechanism of opioid tolerance is still in full swing, there is no doubt that the imbalance of the desensitizationinternalizationresensitization of MOR plays a crucial role [15], which is also the main focus of our review