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In collaboration with postdocs Tatiana Lima and Martin Minns, Karl helped identify a novel role for Pseudomonas aeruginosa exotoxin S ADP-ribosyltransferase activity in the activation of NLRP3 inflammasome in neutrophils

This was an in vitro study

Structural basis for target protein recognition by the protein disulfide reductase thioredoxin

The experiment was performed three times independently

The activation of nuclear factor erythroid 2related factor 2 has been shown to upregulate glutathione peroxidase 4 and ferritin expression, thereby inhibiting ferroptosis in acinar cells and alleviating pancreatic injury in AP

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