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Hyperglycemia results in the storage of metabolic substrates, causing the accumulation of glycolytic intermediates and the formation of mitochondrial ROS (mtROS) from the electron transport chain (ETC), ultimately inducing mitochondrial dysfunction and energy metabolism imbalance[112, 113]

3.2.6 Noncoding RNAs New evidence also suggests several microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as biomarkers of DCM (95), especially those associated with cardiac inflammation (miRNA-21) and redox signaling (miRNA-221, miRNA-146a, miRNA-34a, miRNA-210, miRNA-19b, miRNA-125b, miRNA-27a, miRNA-155) as well as with cardiac hypertrophy (miRNA-221) and apoptosis (miRNA-34a, miRNA-125b, miRNA-146a, miRNA-155, miRNA-210, miRNA-221) (95)

Finally, rapid and high-throughput screening work should be achieved through precise detection

Results: Quercetin exhibits multifaceted pharmacological activities, including anti-inflammatory, antioxidant, antiapoptotic, hypolipidemic, and hypoglycemic effects

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[DOI] [PubMed] [Google Scholar] 31.Finkel T., Holbrook N.J