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However, in rare cases where central obesity is not present, liposuction may still be considered for individuals with a higher BMI.3,37,40 Although many studies reported improving the disease's symptoms, such as reduction of spontaneous pain, bruising, and mobility impairment, there is still not enough evidence to support liposuction as the gold standard in treating lipedema.37,54 It is also important to highlight that liposuction carries risks and potential complications, including post-procedural pain, infection, prolonged recovery, scarring, bruising, ecchymosis, edema, and substantial financial costs, which must be carefully considered in clinical decision-making.54 Bariatric surgery Bariatric surgery may be considered for individuals with lipedema and a BMI 40 kg/m2, and potentially for those with a BMI between 3540 kg/m2

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Finally, hydrogels with good biocompatibility, low immunogenicity, and modifiable physical and chemical properties can be ideal carriers to improve efficacy and reduce the toxicity of natural products (Yegappan et al., 2018

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10.1074/jbc.c400260200 68 KillingerB

Dental amalgam fillings and mercury vapor safety limits in American adults