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Another study revealed that high concentrations of green tea catechins (5%) increased the kidney weight, with no histopathologcal observation 48

Moreover, an enriched subgroup analysis of the URICOI-ICTUS trial revealed that UA treatment was safe, well-tolerated, and provided substantial benefits of UA in terms of the primary outcome(modified Rankin Scale score at day 90)

[28] After inducing the stroke through acute occlusion of the middle cerebral artery, the rats were given 30mg/kg NSI-189 orally, beginning 6 hours after the stroke induction and continuing daily for 12 weeks