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10.1080/07391102.2021.1897682 [DOI] [PubMed] [Google Scholar] Sun B., Lei M., Zhang J., Kang H., Liu H., Zhou F

Our analyses demonstrated that PD patients exhibit significant metabolic reprogramming, characterized by a shift in energy metabolism from the tricarboxylic acid cycle toward glycolysis, a dysregulated urea cycle, and lipid remodeling, as well as extensive activation of inflammatory and immune responses involving the PI3K-Akt, IL-17, NF-kappaB, MAPK and TNF signaling pathways

A study to evaluate the effectiveness and safety of LY03003 in patients with early primary PD (NCT04571164), (2023)

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This interaction promotes Raf's phosphorylation at specific serine and threonine residues, which is vital for its complete activation