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John PC, et al

Diagnosis typically involves blood tests (liver function tests, lipid profile, HbA1c), ultrasound imaging, and assessment for alternative or coexisting causes of liver disease, including alcohol intake, viral hepatitis B and C, autoimmune liver disease, haemochromatosis, and medication-induced liver injury

(77) observed that the non-classical effector proteins Caspase-4/-5/-11 could regulate the tetrapeptide sequence identity of IL-1 and IL-18, thereby modulating IL-1 and IL-18 recruitment and activation, which provides a basis for the development of new therapies for related diseases