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Female BALB/c mice treated with various doses of HCFe nanozyme (20 mg/Kg, 50 mg/Kg, and 100 mg/Kg) exhibited stable body weight, confirming its safety (Fig

Haller et al., 2011)

5.2 Challenges and progress in clinical research Although novel therapies such as ferroptosis inhibitors and mitochondrial protectants have shown promising efficacy in preclinical studies (164, 166, 188), their clinical translation still faces numerous challenges