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INTRODUCTION As one of the driving forces behind the cellular detoxification machinery, glutathione S -transferases (GSTs) and especially the pi class glutathione S -transferase P1 (GSTP1) is currently in the focus of the cancer research community, evaluating the relevance of GSTP1 epimutations for cancer development and its potential as a major epigenetic cancer biomarker

The mCRP isoform, unlike nCRP, has a stimulatory effect on platelets, facilitates thrombus growth through platelet stimulation, and is the more potent reagent, both increasing monocyte activation and ROS production, generated through myeloperoxidase-mediated respiratory burst and raft-associated reduced nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase during oxLDL-mediated foam cell formation (100, 170, 197204)

Incubation with 13 C 3 -serine as an extracellular serine source for 6 h resulted in almost complete labeling of the intracellular serine pool (Fig

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doi:10.1086/341914 Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ (September 2005)

Taken to its extreme, the "epigenetic code" could represent the total state of the cell, with the position of each molecule accounted for in an epigenomic map , a diagrammatic representation of the gene expression, DNA methylation and histone modification status of a particular genomic region