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One of the challenges in this regard is the high degree of responsiveness to treatment seen in first-episode patients [68] (also observed in the current study), compared to those with acute exacerbation of chronic schizophrenia [67]

Even with its complex etiology, genetics is a major factor in the course of the illness [15]

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In LUKE Health, this is implemented with dual-layer PostgreSQL triggers: Layer 1: A database trigger on the orders table checks for an active, non-expired prescription matching the compound being ordered Layer 2: A constraint trigger verifies the prescribing provider's license is valid for the patient's state This isn't application logic that a developer might accidentally bypass during a feature update

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