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doi:10.1016/j.spinee.2014.10.011 6 Bartleson JD, Maus TP

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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

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Human amylin has a strong tendency to aggregate into amyloid fibrils , similarly to amyloid in Alzheimers or -synuclein in Parkinsons