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The transcriptional regulator STAT3 elicits PINK1-dependent mitophagy, which eliminates dysfunctional mitochondria, reverses the collapse of the mitochondrial membrane potential, and represses mtROS release and NLRP3 inflammasomes, whilst STAT3 downregulation protects against osteoclastogenesis (156)

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The evidence presented highlights how chronic ethanol consumption contributes to the onset of depressive disorders through various pathways, including the escalation of oxidative stress, the promotion of neuroinflammation, and the dysregulation of neurotrophic factors

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This observation of higher calcium influx in BD is intriguing in the context of iron overload since calcium and iron have a bidirectional relationship where high Ca +2 influx causes increased LIP and iron overload promotes massive Ca +2 influx [145, 146]