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Most recently, advancements have also been made in the differentiation of mouse embryonic stem cells (mESCs) toward neuroectoderm and neural progenitor cells [144]

10.1002/ana.1001

However, they do not clearly slow disease progression and often cause gastrointestinal (GI) side effects like nausea, diarrhea, and vomiting [28]

GM have been shown to produce amyloid, lipopolysaccharide (LPS), or other biological substances that disrupt intestinal homeostasis, affect the central nervous system through the MGB axis, and mediate the pathological process of NDs, such as inflammation, amyloid, and Tau protein accumulation in the brain (Friedland, 2015

In fact, in zinc deficient-obesity, leptin rise promoted the increase in macrophage infiltration in adipose tissue of mice fed a high-fat diet (108)

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