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Obstruction of the ureter leads to ferroptosis in renal tubular epithelial cells, which in turn causes the secretion of various fibrogenic factors and affects interstitial fibroblasts in a paracrine manner, promoting their proliferation and differentiation (128)

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To maintain a moderate weight, also try to eat more healthfully and engage in regular exercise.

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Clear conclusions from most studies were hampered by the fact that they were carried out in small groups, often of one gender and with differences in exposure temperature and salt composition of the water

A trial performing a direct comparison of fenofibrate versus these more invasive treatments in monotherapy is unlikely to happen, but there have been some attempts at assessing their potential use in combination