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Deficiency can lead to macrocytic anaemia, neurological symptoms including peripheral neuropathy, cognitive changes, and fatigue

Together, these changes significantly lower the analogs affinity for IGF-binding proteins the regulatory proteins that normally limit how much circulating IGF-1 reaches cellular receptors

So, in general vitamin B12 IV therapy would be the most beneficial for: People with vitamin B12 deficiency and related anemia

For laboratory research only

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Sub-optimal levels of B12 can lead the body to express symptoms of tiredness, fatigue, malaise, poor memory and reduced mental function, also referred to as mental fog