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Although 2-deoxy-d-glucose monotherapy has partial efficacy in improving disease in lupus-prone mice, when combined with metformin, a mitochondrial electron transport chain complex I inhibitor, it leads to normalization of T cell metabolism and reversal of disease activity ( Although many reports have shown that some metabolic pathways involving amino acids including glutamine, tryptophan, and cysteine can serve as therapeutic targets in lupus-prone mice, the tentative therapeutic targeting of metabolic pathways of other amino acids remains unclear

Lactate: the ugly duckling of energy metabolism