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Long term prescription of medications such as the following are likely to increase the cause of, or exacerbate the risk of B12 deficiency - the proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole), famotidine, ranitidine, metformin, glibenclamide, gliclazide, glimepiride, glipizide, sodium valproate, gabapentin, doxycycline, some oral contraceptives

van de Donk N, Richardson PG, Malavasi F

It is important to note that while B vitamins have well-established roles in the body, claims regarding specific health benefits should be supported by scientific evidence

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So, without these vitamins, enzymes remain inactive and cannot catalyze specific methylation reactions for the synthesis, activation, or degradation of hormones

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